Holly A Aliesky Selected Research

Graves Disease (Basedow Disease)

1/2019	A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
1/2019	Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice.
12/2016	Critical Differences between Induced and Spontaneous Mouse Models of Graves' Disease with Implications for Antigen-Specific Immunotherapy in Humans.
6/2015	Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease.
5/2015	A unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor.
7/2011	An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.
1/2011	Exceptional hyperthyroidism and a role for both major histocompatibility class I and class II genes in a murine model of Graves' disease.
8/2009	Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies.
6/2009	Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.
4/2008	Shared and unique susceptibility genes in a mouse model of Graves' disease determined in BXH and CXB recombinant inbred mice.

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Holly A Aliesky Research Topics

Disease

14	Hyperthyroidism 01/2019 - 05/2006
12	Graves Disease (Basedow Disease) 01/2019 - 05/2006
7	Thyroiditis 01/2019 - 12/2007
3	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 09/2010
3	Hypothyroidism 08/2018 - 12/2007
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022
1	Cataract (Cataracts) 01/2022
1	Disease Progression 01/2022
1	Goiter 01/2018
1	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 01/2018
1	Thyrotoxicosis 05/2015
1	Genetic Predisposition to Disease (Genetic Predisposition) 03/2013
1	Bacterial Infections (Bacterial Infection) 01/2012
1	Hyperplasia 01/2011
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 06/2009
1	Vitamin D Deficiency 02/2009

Drug/Important Bio-Agent (IBA)

15	Thyrotropin Receptors (Thyrotropin Receptor)IBA 01/2019 - 05/2006
10	AutoantibodiesIBA 01/2022 - 12/2007
8	AntibodiesIBA 09/2012 - 12/2007
5	Iodide Peroxidase (Deiodinase)IBA 01/2019 - 12/2007
5	Thyroglobulin FDA Link 01/2019 - 12/2007
3	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2019 - 03/2013
3	IodidesIBA 08/2018 - 01/2017
3	IodineIBA 01/2018 - 05/2015
3	Protein Subunits (Protein Subunit)IBA 12/2016 - 08/2009
3	Proteins (Proteins, Gene)FDA Link 01/2012 - 08/2009
3	AutoantigensIBA 01/2012 - 06/2009
2	Thyroid-Stimulating ImmunoglobulinsIBA 03/2013 - 12/2007
2	EpitopesIBA 01/2012 - 08/2009
1	Transcription Factors (Transcription Factor)IBA 08/2018
1	Colloids (Colloid)IBA 01/2018
1	AntigensIBA 12/2016
1	Thyroid HormonesIBA 05/2015
1	LigandsIBA 03/2013
1	DNA (Deoxyribonucleic Acid)IBA 09/2012
1	Freund's AdjuvantIBA 01/2012
1	LH Receptors (LH Receptor)IBA 07/2011
1	Vitamin D FDA LinkGeneric 02/2009
1	Long-Acting Thyroid Stimulator (LATS)IBA 06/2006
1	CD40 Ligand (CD40L)IBA 05/2006
1	Abatacept (Orencia)FDA Link 05/2006

Therapy/Procedure

2	Therapeutics 01/2022 - 12/2016
2	Immunotherapy 12/2016 - 05/2015